A multi modal interface for a visually impaired pupils educational environment

The aim of this paper is to describe a multi modal user interface integrated within an architecture allowing visually impaired pupils and sighted people to work on the same station. This architecture is developed to face the problem of the inclusion of visually impaired pupils in mainstream education. The system is able to display the same original multi-media content converted in different ways on screen, Braille terminal and vocal synthesizers. It accepts various interactions from keyboard, Braille bar and mouse. Both blind and sighted users can manage the same tools, cooperate together on the same content, and thus perform the same activities. Blind pupils may be assisted by sighted teachers or tutors that don’t know how to read Braille characters

Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease

Acknowledgments: Depolymerised bovine tubulin was kindly donated by J. Kilmartin (MRC Laboratory of Molecular Biology, Cambridge). This work was supported by the Medical Research Council (UK), a Wellcome Trust Studentship to RL, the Leopold Muller Estate, and the Newton Trust (Trinity College, Cambridge). We gratefully acknowledge Academic Books for permission to use Table 2 and Figures 2–4 which correspond to Table 1 and Figures 20–22 from Wischik C.M., Lai, R.Y.K. and Harrington, C.R. Modelling prion-like processing of tau protein in Alzheimer’s disease for pharmaceutical development, in Brain Microtubule Associated Proteins: Modifications in Disease, Avila, J.; Brandt, R.; Kosik, K.S., Eds. Harwood Academic Publishers: Amsterdam, The Netherlands, 1997. Erratum published on 12 August 2016, see Biomolecules 2016, 6(3), 35. http://www.mdpi.com/2218-273X/6/3/35Peer reviewedPublisher PD

Droplet actuation induced by coalescence: experimental evidences and phenomenological modeling

This paper considers the interaction between two droplets placed on a substrate in immediate vicinity. We show here that when the two droplets are of different fluids and especially when one of the droplet is highly volatile, a wealth of fascinating phenomena can be observed. In particular, the interaction may result in the actuation of the droplet system, i.e. its displacement over a finite length. In order to control this displacement, we consider droplets confined on a hydrophilic stripe created by plasma-treating a PDMS substrate. This controlled actuation opens up unexplored opportunities in the field of microfluidics. In order to explain the observed actuation phenomenon, we propose a simple phenomenological model based on Newton's second law and a simple balance between the driving force arising from surface energy gradients and the viscous resistive force. This simple model is able to reproduce qualitatively and quantitatively the observed droplet dynamics

A Measurement of Small Scale Structure in the 2.2 < z < 4.2 Lyman-alpha Forest

The amplitude of fluctuations in the Ly-a forest on small spatial scales is sensitive to the temperature of the IGM and its spatial fluctuations. The temperature of the IGM and its spatial variations contain important information about hydrogen and helium reionization. We present a new measurement of the small-scale structure in the Ly-a forest from 40 high resolution, high signal-to-noise, VLT spectra at z=2.2-4.2. We convolve each Ly-a forest spectrum with a suitably chosen wavelet filter, which allows us to extract the amount of small-scale structure in the forest as a function of position across each spectrum. We compare these measurements with high resolution hydrodynamic simulations of the Ly-a forest which track more than 2 billion particles. This comparison suggests that the IGM temperature close to the cosmic mean density (T_0) peaks near z=3.4, at which point it is greater than 20,000 K at 2-sigma confidence. The temperature at lower redshift is consistent with the fall-off expected from adiabatic cooling ($T_0 \propto (1+z)^2$), after the peak temperature is reached near z=3.4. At z=4.2 our results favor a temperature of T_0 = 15-20,000 K. However, owing mostly to uncertainties in the mean transmitted flux at this redshift, a cooler IGM model with T_0 = 10,000 K is only disfavored at the 2-sigma level here, although such cool IGM models are strongly discrepant with the z ~ 3-3.4 measurement. We do not detect large spatial fluctuations in the IGM temperature at any redshift covered by our data set. The simplest interpretation of our measurements is that HeII reionization completes sometime near z ~ 3.4, although statistical uncertainties are still large [Abridged].Comment: Submitted to ApJ. Best printed in colo

CP debugging needs and tools

Conventional programming techniques are not well suited for solving many highly combinatorial industrial problems, like scheduling, decision making, resource allocation or planning. Constraint Programming (CP), an emerging software technology, offers an original approach allowing for efficient and flexible solving of complex problems, through combined implementation of various constraint solvers and expert heuristics. Its applications are increasingly elded in various industries

HeII Reionization and its Effect on the IGM

Observations of the intergalactic medium (IGM) suggest that quasars reionize HeII in the IGM at z ~ 3. We have run a set of 190 and 430 comoving Mpc simulations of HeII being reionized by quasars to develop an understanding of the nature of HeII reionization and its potential impact on observables. We find that HeII reionization heats regions in the IGM by as much as 25,000 K above the temperature that is expected otherwise, with the volume-averaged temperature increasing by ~ 12,000 K and with large temperature fluctuations on ~ 50 Mpc scales. Much of the heating occurs far from QSOs by hard photons. We find a temperature-density equation of state of gamma -1 ~ 0.3 during HeII reionization, but with a wide dispersion in this relation having sigma ~ 10^4 K. HeII reionization by the observed population of quasars cannot produce an inverted relation (gamma - 1 < 0). Our simulations are consistent with the observed evolution in the mean transmission of the HeII Ly-alpha forest. We argue that the heat input due to HeII reionization is unable to cause the observed depression at z = 3.2 in the HI Ly-alpha forest opacity as has been suggested. We investigate how uncertainties in the properties of QSOs and of HeII Lyman-limit systems influence our predictions.Comment: 19 pages, 15 figures, plus 9 pages of Appendix. accepted by Ap

Therapeutic Potential of Ralimetinib, a p38/MAPK14 Inhibitor, in Anaplastic Thyroid Cancer

View full abstracthttps://openworks.mdanderson.org/leading-edge/1028/thumbnail.jp

CP debugging tools: Clarification of functionalities and selection of the tools

Abstract is not available

Statistical approach for unpolarized fragmentation functions for the octet baryons

A statistical model for the parton distributions in the nucleon has proven its efficiency in the analysis of deep inelastic scattering data, so we propose to extend this approach to the description of unpolarized fragmentation functions for the octet baryons. The characteristics of the model are determined by using some data on the inclusive production of proton and $\Lambda$ in unpolarized deep inelastic scattering and a next-to-leading analysis of the available experimental data on the production of unpolarized octet baryons in $e^+e^-$ annihilation. Our results show that both parton distributions and fragmentation functions are compatible with the statistical approach, in terms of a few free parameters, whose interpretation will be discussed.Comment: 14 pages, 7 eps figures, to appear in Phys. Rev.